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Chemical Technology

The Laboratory for Chemical Technology (LCT) integrates chemical science and engineering in its research on catalysis, polymerization, kinetics, reactor design and process design. LCT is part of the Department of Materials, Textiles and Chemical Engineering within the Faculty of Engineering and Architecture at Ghent University in Belgium and member of the Centre for Sustainable Chemistry (CSC) of Ghent University.

Science contribution regarding automated continuous synthesis of organic compounds

(07-10-2019)

During a collaboration between the LCT and the Chemical Engineering Department of the Massachusetts Institute of Technology, LCT researcher Pieter Plehiers contributed to the software that allowed a robot to semi-autonomously carry out the full process of synthesizing a target chemical – including suggesting a limited number of synthetic routes with a high evaluated likelihood of success and automatically configuring a continuous flow setup, based on the selected synthesis and required unit operations. The platform – which forms a significant step in automating the process of drug development – is presented in Science (SCI-IF 2018: 41.04) as research article, titled “A robotic platform for flow synthesis of organic compounds informed by AI planning”
The authors are Connor W. Coley, Dale A. Thomas III, Justin A. M. Lummiss, Jonathan N. Jaworski, Christopher P. Breen, Victor Schultz, Travis Hart, Joshua S. Fishman, Luke Rogers, Hanyu Gao, Robert W. Hicklin, Pieter P. Plehiers, Joshua Byington, John S. Piotti, William H. Green, A. John Hart, Timothy F. Jamison, and Klavs F. Jensen
More information can be found via: https://science.sciencemag.org/content/365/6453/eaax1566